Ernst A, Gordon F D, Hayek J, Silvestri R C, Koziel H
Division of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.
Transplantation. 1998 Jan 15;65(1):130-4. doi: 10.1097/00007890-199801150-00025.
Legionella micdadei (Pittsburgh pneumonia agent) is the second most common cause of Legionella pneumonia, and occurs predominantly in immunocompromised hosts. L micdadei is the cause of nosocomial pneumonia in renal transplant recipients, but has not been described in other adult solid organ transplant recipients. This report describes the first case of L micdadei pneumonia in an adult liver transplant recipient on immunosuppressive therapy. Importantly, this case highlights the difficulties in establishing the diagnosis, as the Legionella urinary antigen is negative, and special culture conditions are required. Furthermore, this case illustrates several atypical clinical features of L micdadei pneumonia in a transplant recipient, including a community acquired mode of transmission, occurrence several years after organ transplantation, and lung abcess formation. The patient was successfully treated with limited surgical resection and quinolone antimicrobial monotherapy.
米克戴德军团菌(匹兹堡肺炎病原体)是军团菌肺炎的第二大常见病因,主要发生在免疫功能低下的宿主中。米克戴德军团菌是肾移植受者医院获得性肺炎的病因,但在其他成人实体器官移植受者中尚未见报道。本报告描述了首例接受免疫抑制治疗的成人肝移植受者发生米克戴德军团菌肺炎的病例。重要的是,该病例突出了诊断的困难,因为军团菌尿抗原为阴性,且需要特殊的培养条件。此外,该病例说明了移植受者中米克戴德军团菌肺炎的几个非典型临床特征,包括社区获得性传播模式、器官移植数年之后发病以及肺脓肿形成。患者通过有限的手术切除和喹诺酮类抗菌药物单药治疗获得成功治愈。