功能性脑成像背后的故事：历史与生理学视角
Behind the scenes of functional brain imaging: a historical and physiological perspective.
作者信息
Raichle M E
机构信息
Washington University School of Medicine, 4525 Scott Avenue, St. Louis, MO 63110, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):765-72. doi: 10.1073/pnas.95.3.765.
Abstract
At the forefront of cognitive neuroscience research in normal humans are the new techniques of functional brain imaging: positron emission tomography and magnetic resonance imaging. The signal used by positron emission tomography is based on the fact that changes in the cellular activity of the brain of normal, awake humans and laboratory animals are accompanied almost invariably by changes in local blood flow. This robust, empirical relationship has fascinated scientists for well over a hundred years. Because the changes in blood flow are accompanied by lesser changes in oxygen consumption, local changes in brain oxygen content occur at the sites of activation and provide the basis for the signal used by magnetic resonance imaging. The biological basis for these signals is now an area of intense research stimulated by the interest in these tools for cognitive neuroscience research.
摘要
在正常人类认知神经科学研究的前沿是功能性脑成像新技术
正电子发射断层扫描和磁共振成像。正电子发射断层扫描所使用的信号基于这样一个事实，即正常、清醒的人类和实验动物大脑的细胞活动变化几乎总是伴随着局部血流的变化。这种稳固的经验关系已经吸引科学家们长达一百多年。由于血流变化伴随着氧气消耗的较小变化，大脑氧含量的局部变化发生在激活部位，并为磁共振成像所使用的信号提供了基础。这些信号的生物学基础现在是一个受到认知神经科学研究工具兴趣刺激的深入研究领域。
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