Hekimi S, Lakowski B, Barnes T M, Ewbank J J
Department of Biology, McGill University, Montréal, Québec, Canada.
Trends Genet. 1998 Jan;14(1):14-20. doi: 10.1016/S0168-9525(97)01299-7.
Several loci have been identified in the nematode worm Caenorhabditis elegans that, when mutated, can increase life span. Three of these genes, age-1, daf-2 and clk-1, have now been cloned. Mutations in these three genes are highly pleiotropic and affect many aspects of worm development and behaviour, age-1 and daf-2 act in the same genetic pathway and have similar effects on the worm, age-1 encodes a homologue of the p110 subunit of phosphatidylinositol 3-kinase and daf-2 encodes an insulin receptor family member, clk-1 encodes a protein of unknown biochemical function similar to the yeast metabolic regulator Cat5p/Coq7p. The implications of these findings for our understanding of organismal ageing are discussed.
在线虫秀丽隐杆线虫中已经鉴定出了几个位点，这些位点发生突变时可延长寿命。其中三个基因，即age-1、daf-2和clk-1，现已被克隆。这三个基因的突变具有高度多效性，会影响线虫发育和行为的许多方面，age-1和daf-2作用于相同的遗传途径，对线虫有相似的影响，age-1编码磷脂酰肌醇3激酶p110亚基的同源物，daf-2编码胰岛素受体家族成员，clk-1编码一种生化功能未知的蛋白质，类似于酵母代谢调节因子Cat5p/Coq7p。本文讨论了这些发现对我们理解生物体衰老的意义。
