Lobo M J, Remesar X, Alemany M
Departament de Bioquímica i Fisiologia, Universitat de Barcelona, Spain.
Biochem Mol Biol Int. 1993 Feb;29(2):349-58.
The effects of the constant infusion with mini-osmotic pumps of several steroid hormones on body weight, energy balance and protein/lipid/water composition in young female rats has been studied for a period of 15 days. Despite unchanged food consumption, progesterone strongly induced fat deposition, with higher protein accrual efficiency coupled with lowered energy losses through thermogenesis. Estrogens lowered body weight but maintained higher protein levels and protein accrual rates; beta-estradiol induced the loss of lipid and diminished food intake. Heat production was unchanged or lower in all estrogen-treated animals; beta-estradiol had a more marked effect on body weight (through food intake, heat production and lipid mobilization/storage combined) than estrone. Testosterone and 5-androstenediol increased the proportion of protein, but none of them had a significant effect on lipid deposition or heat production. Nortestosterone, increased energy expenditure, fuelled in part by a higher food ingestion, a trait shared by 4-androstenedione, but not by the other androgens. The effect of androgens on body weight may thus be a combination of their actions on a) food intake, b) efficiency of protein deposition and c) activation of heat production or of lipid (energy) storage. Practically all increased the efficiency of protein deposition. Nortestosterone increased heat production. Androstenedione increased lipid storage. Dehydroepiandrosterone did not decrease body weight or metabolic rate. Cortisol depressed heat production and food intake, with a net loss of weight. Cortisol and cortisone did not increase protein deposition, but corticosterone did; deoxycorticosterone showed a high efficiency of protein deposition and increased the size of fat stores, also increasing the metabolic rate by a mean 26% versus controls, compared with a reduction of about the same magnitude induced by cortisol. The data presented suggest that cortisol-cortisone and corticosterone may represent two distinct groups of glucocorticoids.
利用微型渗透泵持续输注几种甾体激素对年轻雌性大鼠体重、能量平衡及蛋白质/脂质/水成分的影响已进行了为期15天的研究。尽管食物摄入量未变，但孕酮强烈诱导脂肪沉积，蛋白质积累效率更高，同时通过产热导致的能量损失降低。雌激素降低体重，但维持较高的蛋白质水平和蛋白质积累率；β-雌二醇导致脂质流失并减少食物摄入量。所有接受雌激素治疗的动物产热未变或降低；β-雌二醇对体重的影响（通过食物摄入、产热和脂质动员/储存综合作用）比雌酮更显著。睾酮和5-雄烯二酮增加了蛋白质比例，但它们对脂质沉积或产热均无显著影响。诺乙睾酮增加能量消耗，部分原因是食物摄入量增加，4-雄烯二酮也有此特点，但其他雄激素没有。雄激素对体重的影响可能是它们对以下方面作用的综合结果：a）食物摄入，b）蛋白质沉积效率，c）产热激活或脂质（能量）储存激活。实际上所有雄激素都提高了蛋白质沉积效率。诺乙睾酮增加产热。雄烯二酮增加脂质储存。脱氢表雄酮未降低体重或代谢率。皮质醇抑制产热和食物摄入，导致体重净损失。皮质醇和可的松未增加蛋白质沉积，但皮质酮增加了；脱氧皮质酮显示出较高的蛋白质沉积效率，增加了脂肪储存量，与对照组相比，代谢率平均提高26%，而皮质醇诱导的代谢率降低幅度约与此相同。所呈现的数据表明，皮质醇-可的松和皮质酮可能代表两类不同的糖皮质激素。
