Moffat J A, Jhamandas K
Eur J Pharmacol. 1976 Apr;36(2):289-97. doi: 10.1016/0014-2999(76)90082-0.
Effects of in vitro methadone and several other narcotics were investigated on 3H-5-HT uptake in rat hypothalamus slices. The results indicated that d, l-methadone and levorphanol had slightly greater inhibitory action on the uptake than the isomers, d-methadone and dextrorphan, respectively. Morphine, diacetylmorphine and the narcotic antagonist naloxone produced a considerably weaker inhibitory effect. After an acute injection of methadone, but not morphine, the uptake of 5-HT by hypothalamic slices of treated animals was inhibited. The chronic treatment of rats with methadone for 18 days had no significant effect on the uptake, but following the withdrawal of this treatment for 2 weeks the 5-HT uptake was significantly elevated. The inhibitory effects of in vitro methadone in the hypothalamus slices were not modified by the chronic drug treatment.
研究了体外美沙酮和其他几种麻醉药对大鼠下丘脑切片中3H-5-羟色胺（3H-5-HT）摄取的影响。结果表明，消旋美沙酮和左啡诺对摄取的抑制作用分别比其异构体右旋美沙酮和右啡烷稍强。吗啡、二乙酰吗啡和麻醉拮抗剂纳洛酮产生的抑制作用明显较弱。急性注射美沙酮后，而非吗啡，处理动物下丘脑切片对5-HT的摄取受到抑制。用美沙酮对大鼠进行18天的慢性处理对摄取没有显著影响，但在停药2周后，5-HT摄取显著升高。下丘脑切片中美沙酮的体外抑制作用不受慢性药物处理的影响。
