特应性皮炎患者表皮中儿茶酚胺合成与降解的改变。
Altered catecholamine synthesis and degradation in the epidermis of patients with atopic eczema.
作者信息
Schallreuter K U, Pittelkow M R, Swanson N N, Beazley W D, Körner C, Ehrke C, Büttner G
机构信息
Clinical and Experimental Dermatology Department of Biomedical Sciences, University of Bradford, UK.
出版信息
Arch Dermatol Res. 1997 Nov;289(12):663-6. doi: 10.1007/s004030050258.
Patients with atopic eczema have significantly higher norepinephrine levels in plasma than healthy controls. In addition, significantly higher levels of the essential cofactor (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (6BH4) were found in this patient group. Cell extracts from epidermal suction blister roofs revealed only half the normal activity of phenylethanolamine-N-methyl transferase (PNMT) together with a threefold induction of the norepinephrine-degrading enzyme monoamine oxidase A (MAO-A). Taken together, these results support earlier observations of a defective catecholamine/adrenoceptor signal in patients with atopic eczema.
特应性皮炎患者血浆中的去甲肾上腺素水平显著高于健康对照组。此外，在该患者组中发现必需辅因子（6R）-L-赤藓糖-5,6,7,8-四氢生物蝶呤（6BH4）的水平也显著更高。表皮抽吸疱顶的细胞提取物显示苯乙醇胺-N-甲基转移酶（PNMT）的活性仅为正常水平的一半，而去甲肾上腺素降解酶单胺氧化酶A（MAO-A）的活性则诱导了三倍。综上所述，这些结果支持了早期关于特应性皮炎患者儿茶酚胺/肾上腺素能受体信号缺陷的观察结果。
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