Kim H R, Buchanan J W, D'Antonio R, Larson S M, Morgan R P, Thorell J I, McIintyre P A, Wagner H N
J Nucl Med. 1976 Aug;17(8):737-9.
Serum from the oyster toadfish, Opsanus tau, has a binding capacity for cyanocobalamin 1,000 times greater than that of human serum. The binding follows the principle of isotope dilution in the physiologic range of vitamin B12 present in human serum. Under proper conditions of storage, this binder is stable for at least 1 year. Standard reagents and techniques used in other vitamin B12 competitive binding assays can be used with the toadfish serum binder. Toadfish serum offers potential advantages over intrinsic factor and human serum, the most commonly used binders in vitamin B12 assays.
海湾蟾鱼（Opsanus tau）的血清对钴胺素的结合能力比人类血清高1000倍。在人类血清中维生素B12的生理范围内，这种结合遵循同位素稀释原理。在适当的储存条件下，这种结合剂至少可稳定保存1年。其他维生素B12竞争性结合测定中使用的标准试剂和技术可用于海湾蟾鱼血清结合剂。与维生素B12测定中最常用的结合剂——内因子和人类血清相比，海湾蟾鱼血清具有潜在优势。
