Kozhedub R G
Zh Vyssh Nerv Deiat Im I P Pavlova. 1997 Sep-Oct;47(5):870-7.
The universal principle of brain operation which consists in initial global non-specific reactions and secondary local specific changes is reflected at the behavioral level in the dominant properties of the generalization stage of conditioned reflex and its transition to the specialization stage. These phenomena correspond at the cellular level to a temporary increase in excitability of cortical neurons and long-term modifications of synaptic efficacy in interneuronal excitatory and inhibitory connections. Such a sequence of events is largely determined by the dynamics of hypothalamic-cortical integration and operation of N-methyl-D-aspartate (NMDA) receptor-channel complex. Increase in cell excitability which results at the initial stage of learning in a transition of cells to burst discharge mode of unit activity and is accompanied by pronounced generalized synchronization of slow electrical activity in the theta-rhythm range promotes manifestation of synaptic modifications, which, in turn, determine a specialized conditioned motor act at the terminal stage.
大脑运作的普遍原则包括初始的全局非特异性反应和继发的局部特异性变化，这在行为层面上反映在条件反射泛化阶段及其向分化阶段转变的主导特性中。这些现象在细胞层面上对应于皮质神经元兴奋性的暂时增加以及神经元间兴奋性和抑制性连接中突触效能的长期改变。这样一系列事件在很大程度上由下丘脑 - 皮质整合的动态过程以及N - 甲基 - D - 天冬氨酸（NMDA）受体 - 通道复合体的运作所决定。在学习初始阶段，细胞兴奋性增加导致细胞转变为单位活动的爆发式放电模式，并伴随着θ节律范围内缓慢电活动的明显广泛同步化，这促进了突触修饰的表现，而突触修饰反过来又决定了末期阶段专门的条件性运动行为。
