[Long-term changes in synaptic efficiency and cellular excitability during learning].

Temporal analysis of changes of pyramidal tract response on the model of prolonged potentiation revealed the significant role of the mechanism of increase of the cell general excitability at the initial stage of trace processes formation ("dominant" analogue) what probably contributes to better consolidation of basic CR mechanism--the increase of synaptic links efficiency. During the elaboration of CR to stimulation of two cortical points the increase of cellular excitability was more expressed in those experiments where the reinforcement was supplemented by stimulation of the lateral hypothalamus eliciting alimentary reaction. These data allow to consider the membrane plasticity to be a cortical mechanism of motivational reinforcement component determining dominant properties of CR generalization stage.