Kozhedub R G
Zh Vyssh Nerv Deiat Im I P Pavlova. 1992 Jul-Aug;42(4):664-71.
In experiments with noncurarized and unanaesthetized rabbits was recorded pyramidal tract response in the course of conditioning of direct stimulations of the two points of the cortical surface. The data obtained point to temporary specificity in manifestation of the membrane and synaptic plasticity, to participation of these mechanisms in the processes proceeding in both cortical representations of paired stimuli, and to predominantly undirected changes of a degree of their involvement in both cortical areas. At the early stage of conditioning were demonstrated all the characteristics of the dominant state developing at this stage, and at the late one those of differential conditioning. A conclusion is drown that the reinforcement through the membrane plasticity leads to initial dominant increase of cellular excitability. On the background of the latter by means of summation mechanism the conditions are created for excitation transmission from the sensory link of a new bond to its motor output. Underlined by the mechanisms of synaptic plasticity gradual reorganization of the excitatory and inhibitory connections to the output elements of conditioned response determines and consolidates specialized character of the elaborated reaction.
在对未用箭毒处理和未麻醉的兔子进行的实验中，记录了在对皮质表面两点进行直接刺激的条件反射过程中锥体束反应。所获得的数据表明，膜和突触可塑性表现具有暂时特异性，这些机制参与了成对刺激的两个皮质表征中进行的过程，并且主要是两个皮质区域中其参与程度的无定向变化。在条件反射的早期阶段，表现出了该阶段发展的优势状态的所有特征，而在后期则表现出了分化性条件反射的特征。得出的结论是，通过膜可塑性进行的强化导致细胞兴奋性最初的优势增加。在后者的背景下，通过总和机制为从新联结的感觉环节到其运动输出的兴奋传递创造了条件。由突触可塑性机制强调的对条件反应输出元件的兴奋性和抑制性连接的逐渐重组，决定并巩固了所形成反应的特殊性质。
