Balda M S, Matter K
Department of Cell Biology, University of Geneva, Geneva, Switzerland.
J Cell Sci. 1998 Mar;111 ( Pt 5):541-7. doi: 10.1242/jcs.111.5.541.
Tight junctions are the most apical intercellular junctions of epithelial and endothelial cells and create a regulatable semipermeable diffusion barrier between individual cells. On a cellular level, they form an intramembrane diffusion fence that restricts the intermixing of apical and basolateral membrane components. In addition to these well defined functions, more recent evidence suggests that tight junctions are also involved in basic cellular processes like the regulation of cell growth and differentiation.
紧密连接是上皮细胞和内皮细胞最顶端的细胞间连接，在单个细胞之间形成一个可调节的半透性扩散屏障。在细胞水平上，它们形成一个膜内扩散屏障，限制顶端和基底外侧膜成分的混合。除了这些明确的功能外，最近的证据表明紧密连接也参与细胞生长和分化调节等基本细胞过程。
