Ferlito A, Antonutto G, Silvestri F
ORL J Otorhinolaryngol Relat Spec. 1976;38(2):65-85. doi: 10.1159/000275260.
Of the 12 cases of verrusous squamous cell carcinoma of the larynx encountered since 1968 at the Department of Otolaryngology of Padua University (including the Verona Section) and the Department of Pathologic Anatomy of the University of Trieste, three are reported, together with an investigation of the nuclear DNA content of the tumour cells. It is suggested that such a study may assit with early detection of verrucous carcinoma. The laryngeal localization of the neoplasm has been evidenced only in some centres. The difficulties in establishing a correct diagnosis for this variant of squamous cell carcinoma are emphasized and the pathomorphological features, as well as the microscopic and macroscopic appearances, are discussed. The prognosis is excellent and the therapy of choice must be only surgical, as radiation has not only proven ineffective, but in some cases has induced anaplasia, leading to a rapid dissemination of the tumour.
自1968年以来，在帕多瓦大学（包括维罗纳分校）耳鼻喉科以及的里雅斯特大学病理解剖科所遇到的12例喉疣状鳞状细胞癌中，本文报告了其中3例，并对肿瘤细胞的核DNA含量进行了研究。研究表明，这样的研究可能有助于早期发现疣状癌。该肿瘤仅在一些中心有喉部定位的报道。文中强调了对这种鳞状细胞癌变体进行正确诊断的困难，并讨论了其病理形态学特征以及微观和宏观表现。其预后良好，首选治疗方法必须是手术，因为放疗不仅已被证明无效，而且在某些情况下还会诱发间变，导致肿瘤迅速扩散。
