Ray Jay Gopal, Mukherjee Sanjit, Pattanayak Mohanty Sweta, Chaudhuri Keya
Department of Oral and Maxillofacial Pathology, Dr R Ahmed Dental College and Hospital, Kolkata, West Bengal, India.
BMJ Case Rep. 2011 May 3;2011:bcr1120103479. doi: 10.1136/bcr.11.2010.3479.
The clinico-histopathological diagnosis of oral verrucous carcinoma (OVC) is often exclusionary and extremely difficult. Distinction from the classical oral squamous-cell carcinoma (OSCC) is a frequent problem for both clinicians and pathologists because of the extensive nature of the lesion mimicking an invasive cancer. Immunohistochemistry in this case provides a platform for studying distinct molecular mechanism by variation in expression of protein markers. In this study, the authors have attempted to differentiate OVC (case no 1) and OSCC (case no 2) by studying the expression pattern of some well-known tumour marker proteins (vascular endothelial growth factor, matrix metalloproteinases 2 and 9, superoxide dismutase 2 and nicotinamide adenine dinucleotide phosphate quinone oxidoreductase 1). A distinction in expression of these proteins provides a clear understanding that OVC do not show characteristics of a classical carcinoma and may be regarded as a misnomer. This may also provide a better guide for clinicians to differentiate between these two.
口腔疣状癌（OVC）的临床组织病理学诊断通常具有排他性且极为困难。由于病变范围广泛，类似浸润性癌，因此区分经典口腔鳞状细胞癌（OSCC）对临床医生和病理学家来说都是一个常见问题。在此情况下，免疫组织化学为通过蛋白质标志物表达变化研究不同分子机制提供了一个平台。在本研究中，作者试图通过研究一些知名肿瘤标志物蛋白（血管内皮生长因子、基质金属蛋白酶2和9、超氧化物歧化酶2和烟酰胺腺嘌呤二核苷酸磷酸醌氧化还原酶1）的表达模式来区分OVC（病例1）和OSCC（病例2）。这些蛋白质表达的差异清楚地表明，OVC不具有经典癌的特征，这个名称可能并不恰当。这也可能为临床医生区分这两者提供更好的指导。
