Nishi O, Nakai Y, Mizumoto Y, Yamada Y
Nishi Eye Hospital, Osaka, Japan.
J Cataract Refract Surg. 1997 Dec;23(10):1548-55. doi: 10.1016/s0886-3350(97)80028-4.
To describe the features of capsule opacification in rabbits and cynomolgus monkeys after the capsules were refilled with an inflatable endocapsular balloon.
Nishi Eye Hospital, Jinshikai Medical Foundation, Osaka, Japan.
Capsule opacification was evaluated by slitlamp examination, Miyake view, and histopathological examination in 15 eyes of 15 rabbits and 16 eyes of 13 primates from 4 to 32 months after the lens capsule had been refilled.
The incidence of capsule opacification was 94%. In the eyes that did not have lens epithelial cell (LEC) removal, a monolayer of LECs was seen on the posterior capsule when the lens capsule was tautly refilled, whereas a thick layer was seen when the lens capsule was moderately or poorly refilled. In the eyes that had LEC removal, the opacification was generally less marked regardless of the amount of refilling. In two rabbit capsules that were refilled moderately or tautly and had LEC removal, the capsule remained clear. Neodymium:YAG capsulotomy in two eyes did not cause herniation of the injected silicone.
Filling the capsule tautly and removing the LECs effectively reduced capsule opacification but could not completely inhibit LEC migration. This suggests the need for more efficient and thorough LEC removal or even a pharmaceutical approach to prevent capsule opacification after lens refilling.
描述用可充气囊内球囊对兔和食蟹猴晶状体囊进行再填充后晶状体囊混浊的特征。
日本大阪锦石凯医疗基金会西眼科医院。
在晶状体囊再填充后4至32个月，通过裂隙灯检查、三宅视图和组织病理学检查对15只兔的15只眼和13只灵长类动物的16只眼的晶状体囊混浊情况进行评估。
晶状体囊混浊的发生率为94%。在未去除晶状体上皮细胞（LEC）的眼中，当晶状体囊紧密再填充时，后囊可见单层LEC，而当晶状体囊适度或不良再填充时，则可见厚层LEC。在去除了LEC的眼中，无论再填充量如何，混浊通常都不太明显。在两只适度或紧密再填充且去除了LEC的兔晶状体囊中，晶状体囊保持清晰。两只眼中的钕:钇铝石榴石囊切开术未导致注入的硅酮疝出。
紧密填充晶状体囊并去除LEC可有效减少晶状体囊混浊，但不能完全抑制LEC迁移。这表明需要更有效、更彻底地去除LEC，甚至采用药物方法来预防晶状体再填充后的晶状体囊混浊。
