Rapaport F T, Bachvaroff R J
Ann Surg. 1976 Jul;184(1):51-9. doi: 10.1097/00000658-197607000-00009.
Severe thermal injury has the capacity to increase the rate of generation of antibody-forming cells in mice. The intensity of stimulation appears to be proportional to the extent of injury. The effect has been observed in animals burned within 1 hr before or after sensitization with test antigen(s), and persists up to 14 days after injury. Thereafter, the stimulatory effect wanes, and disappears by the 21st day after burning. Responses to T-cell (thymus derived lymphocytes) dependent antigens (sheep erythrocytes; sheep erythrocytes coupled to TNP) and to antigens not requiring T and B-cell (bone marrow derived lymphocytes) cooperation (DNP-Ficoll) appear to be equally affected by thermal injury. The mechanisms underlying this form of enhanced antibody response are not clear. The data, however, support the possibility that the burn wound may release factor(s) capable of enhancing humoral responsiveness in the injured animal. Such factor(s) do not appear to be endotoxins.
严重热损伤能够提高小鼠体内抗体形成细胞的生成速率。刺激强度似乎与损伤程度成正比。在用试验抗原致敏前1小时内或致敏后1小时内烧伤的动物中均观察到了这种效应，并且在损伤后持续长达14天。此后，刺激效应逐渐减弱，在烧伤后第21天消失。热损伤对依赖T细胞（胸腺衍生淋巴细胞）的抗原（绵羊红细胞；与TNP偶联的绵羊红细胞）以及对不需要T细胞和B细胞（骨髓衍生淋巴细胞）协同作用的抗原（DNP-菲可）的反应似乎具有同等影响。这种增强抗体反应形式的潜在机制尚不清楚。然而，这些数据支持烧伤创面可能释放能够增强受伤动物体液反应性的因子的可能性。此类因子似乎不是内毒素。
