Nagata C, Kabuto M, Kurisu Y, Shimizu H
Department of Public Health, Gifu University School of Medicine, Japan.
Nutr Cancer. 1997;29(3):228-33. doi: 10.1080/01635589709514629.
We examined the cross-sectional relationship of soy product intake to serum concentrations of estradiol (E2) and sex hormone-binding globulin (SHBG) in 50 healthy premenopausal Japanese women. Intakes of soy products and various nutrients were estimated through a semiquantitative food-frequency questionnaire. Blood samples were drawn from each subject on Days 11 and 22 of her menstrual cycle. The intake of soy products was inversely correlated with E2 on Days 11 and 22 of the cycle after controlling for age, body mass index, cycle length, and intakes of total energy, fat, and crude fiber (r = -0.23, p = 0.08 and r = -0.32, p = 0.04, respectively). No significant correlation was observed between soy product intake and SHBG. There was a tendency for the intake of individual soy foods such as tofu and miso to be inversely correlated with E2 on Days 11 and 22 of the menstrual cycle. Miso intake was inversely significantly correlated with SHBG on Day 22 of the cycle (r = -0.36, p = 0.02). If the observed association is causal, our results suggest that the consumption of soy products lowers the risk of developing breast cancer risk modifying estrogen metabolism.
我们对50名健康的绝经前日本女性进行了研究，以考察豆制品摄入量与雌二醇（E2）血清浓度及性激素结合球蛋白（SHBG）之间的横断面关系。通过半定量食物频率问卷估算豆制品及各种营养素的摄入量。在每个受试者月经周期的第11天和第22天采集血样。在控制年龄、体重指数、月经周期长度以及总能量、脂肪和粗纤维摄入量后，豆制品摄入量在月经周期的第11天和第22天与E2呈负相关（r分别为-0.23，p = 0.08；r为-0.32，p = 0.04）。未观察到豆制品摄入量与SHBG之间存在显著相关性。在月经周期的第11天和第22天，诸如豆腐和味噌等个别豆制品的摄入量有与E2呈负相关的趋势。在月经周期的第22天，味噌摄入量与SHBG呈显著负相关（r = -0.36，p = 0.02）。如果观察到的关联是因果关系，我们的结果表明，食用豆制品可降低患乳腺癌的风险，调节雌激素代谢。
