Furst D E, Clements P J, Steen V D, Medsger T A, Masi A T, D'Angelo W A, Lachenbruch P A, Grau R G, Seibold J R
Virginia Mason Research Center, Seattle, WA 98101, USA.
J Rheumatol. 1998 Jan;25(1):84-8.
To test the ability of the modified Rodnan skin score to reflect skin thickness in skin biopsies from 141 patients with systemic sclerosis (SSc) obtained at entry during a prospective, double blind study of ketanserin versus placebo in SSc.
Punch skin biopsies (4 mm) were obtained from the dorsal surface of the distal forearm of 141 patients. Biopsy specimens were trimmed and weighed (wet weight) and then desiccated and reweighed (dry weight). Skin score was recorded for 17 areas, graded 0-4+, while edema was graded 0-4+ in 10 of the same sites using finger pressure.
Total skin score correlated with wet weight (r = 0.553) and dry weight (r = 0.517) of the skin biopsies. Local skin score from the biopsied forearm also correlated with wet and dry weight (r = 0.536 and 0.530, respectively). Dry weight as a percentage of wet weight was the same for diffuse cutaneous SSc (dSSc) and limited cutaneous SSc (lSSc) (30.7% for both, NS), despite increased wet weight in patients with dSSc versus lSSc (17.75 vs 13.03 g; p < 0.001). Edema scores correlated poorly both with wet weight (r = 0.069) and dry weight (r = 0.169).
Total and forearm skin score correlates well with both wet and dry forearm skin biopsy weight from forearm biopsies, indicating that skin score reflects the underlying pathology of SSc. Further, the percentage of dry to wet weight is similar for lSSc and dSSc, supporting the usefulness of skin score in differentiating SSc disease subtypes.
在一项关于酮色林与安慰剂治疗系统性硬化症（SSc）的前瞻性双盲研究中，测试改良的罗德南皮肤评分反映141例SSc患者入组时获取的皮肤活检样本中皮肤厚度的能力。
从141例患者的前臂远端背侧获取4毫米的皮肤打孔活检样本。将活检标本修剪并称重（湿重），然后干燥并再次称重（干重）。记录17个区域的皮肤评分，分级为0 - 4+，同时在10个相同部位使用手指按压对水肿进行分级，分级为0 - 4+。
皮肤活检样本的总皮肤评分与湿重（r = 0.553）和干重（r = 0.517）相关。活检前臂的局部皮肤评分也与湿重和干重相关（分别为r = 0.536和0.530）。弥漫性皮肤型SSc（dSSc）和局限性皮肤型SSc（lSSc）的干重占湿重的百分比相同（均为30.7%，无显著性差异），尽管dSSc患者的湿重高于lSSc患者（17.75克对13.03克；p < 0.001）。水肿评分与湿重（r = 0.069）和干重（r = 0.169）的相关性均较差。
总皮肤评分和前臂皮肤评分与前臂活检样本的湿重和干重均密切相关，表明皮肤评分反映了SSc的潜在病理情况。此外，lSSc和dSSc的干重与湿重百分比相似，支持皮肤评分在区分SSc疾病亚型方面的有用性。
