Oksanen A, Bergström M, Sjöstedt S, Gad A, Hammarlund B, Seensalu R
Department of Medical and Surgical Gastroenterology and Hepatology, Karolinska Institute, Huddinge University Hospital, Sweden.
Scand J Clin Lab Invest. 1997 Dec;57(8):689-94. doi: 10.3109/00365519709105230.
The urea breath test (UBT) has been shown to be a reliable non-invasive method for detection of H. pylori infection. There is widespread use of a test meal in the 13C UBT, but to what extent exclusion of the test meal actually influences the accuracy of the test has been poorly investigated. In addition, there is variability between test protocols in breath sampling frequency. In this evaluation, 91 patients with dyspeptic symptoms were investigated in an out-patient endoscopy ward, using a simplified 13C UBT without a test meal, and a single point breath evaluation after ingestion of 13C-labelled urea. Helicobacter pylori infection was diagnosed on upper endoscopy by histology and rapid urease tests on biopsies from the antrum and corpus mucosa of the stomach. Fifty-four percent of the patients had H. pylori infection. With the chosen cut-off level, the sensitivity and specificity of the 13C UBT were 92% and 95%, respectively. We conclude that this simplified 13C UBT is easy to perform and a very reliable test for detecting H. pylori infection, making it a suitable test in routine clinical work.
尿素呼气试验（UBT）已被证明是检测幽门螺杆菌感染的一种可靠的非侵入性方法。在¹³C尿素呼气试验中广泛使用试餐，但排除试餐对试验准确性的实际影响程度尚未得到充分研究。此外，不同的试验方案在呼气采样频率上存在差异。在本评估中，91例有消化不良症状的患者在门诊内镜病房接受了研究，采用了一种不使用试餐的简化¹³C尿素呼气试验，并在摄入¹³C标记的尿素后进行单点呼气评估。通过组织学检查和对取自胃窦和胃体黏膜活检组织的快速尿素酶试验，在内镜检查中诊断幽门螺杆菌感染。54%的患者感染了幽门螺杆菌。在选定的临界值水平下，¹³C尿素呼气试验的敏感性和特异性分别为92%和95%。我们得出结论，这种简化的¹³C尿素呼气试验易于操作，是检测幽门螺杆菌感染的一种非常可靠的试验，使其成为常规临床工作中的合适检测方法。
