Hansen M K, Kapás L, Fang J, Krueger J M
Department of Physiology and Biophysics, University of Tennessee, Memphis 38163, USA.
Am J Physiol. 1998 Jan;274(1):R168-74. doi: 10.1152/ajpregu.1998.274.1.R168.
Feeding rats a cafeteria diet results in increased food intake and excess sleep. Furthermore, vagal afferent activity is altered by a variety of gastrointestinal factors, and vagal stimulation can induce sleep. We investigated, therefore, the hypothesis that the vagal nerve plays a critical role in mediating the sleep-inducing effects of cafeteria feeding. We examined the effects of a cafeteria diet on sleep, electroencephalographic (EEG) slow-wave activity (SWA), and brain temperature (Tbr) in control and vagotomized rats. EEG, electromyogram, and Tbr were recorded for 7 consecutive days. Day 1 was considered a baseline day; normal rat chow was available ad libitum. On days 2-4, the animals were fed, in addition to normal chow, a mixed, energy-rich diet (cafeteria diet). On days 5-7, the rats were again fed only normal rat chow. In control rats, the cafeteria diet resulted in an increase in non-rapid eye movement sleep (NREMS), which was the result of a significant lengthening of the NREMS episodes. In contrast, feeding vagotomized rats the cafeteria diet resulted in a decrease in NREMS. Cafeteria feeding decreased REMS and EEG SWA and increased Tbr in both control and vagotomized rats. These results suggest that an intact vagus plays a key role in the NREMS-inducing effects of the cafeteria diet.
给大鼠喂食自助餐式饮食会导致食物摄入量增加和睡眠过多。此外，迷走神经传入活动会受到多种胃肠道因素的影响，并且迷走神经刺激可诱导睡眠。因此，我们研究了以下假设：迷走神经在介导自助餐式饮食的促睡眠作用中起关键作用。我们研究了自助餐式饮食对对照大鼠和迷走神经切断大鼠的睡眠、脑电图（EEG）慢波活动（SWA）和脑温（Tbr）的影响。连续7天记录EEG、肌电图和Tbr。第1天被视为基线日；正常大鼠饲料可随意获取。在第2 - 4天，除了正常饲料外，给动物喂食混合的高能量饮食（自助餐式饮食）。在第5 - 7天，再次仅给大鼠喂食正常大鼠饲料。在对照大鼠中，自助餐式饮食导致非快速眼动睡眠（NREMS）增加，这是NREMS发作显著延长的结果。相比之下，给迷走神经切断的大鼠喂食自助餐式饮食导致NREMS减少。自助餐式饮食在对照大鼠和迷走神经切断的大鼠中均降低了快速眼动睡眠（REMS）和EEG SWA，并升高了Tbr。这些结果表明，完整的迷走神经在自助餐式饮食诱导NREMS的作用中起关键作用。
