Edrada R A, Proksch P, Wray V, Witte L, van Ofwegen L
Julius-von-Sachs-Institut für Biowissenschaften, Lehrstuhl für Pharmazeutische Biologie, Würzburg, Germany.
J Nat Prod. 1998 Mar;61(3):358-61. doi: 10.1021/np970276t.
The marine soft coral Lobophytum pauciflorum collected from Mindoro Island, Philippines, yielded four new lobane diterpene derivatives: the acetate congeners of epoxylobatrienol and lobatrienediol (2 and 7, respectively), a methoxyl congener of lobatetraene (10), and an oxepin congener of lobatrienetriol (11), and six known derivatives (1, 3-6, and 8). The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, 1H-detected direct, and long-range 13C-1H correlations) and mass spectrometric (EIMS) data. All of the compounds were active against the phytopathogenic fungus Cladosporium cucumerinum. Compound 1 was found to be active against the Gram-positive bacteria Bacillus subtilis and the yeast Saccharomyces cerevisiae. The isolated lobane diterpenes were also active in the brine shrimp lethality test. In the latter bioassay, compounds 8 and 10 were the most active congeners with LC50's of 0.64 and 4.18 micrograms/mL, respectively.
从菲律宾民都洛岛采集的海洋软珊瑚多花短指软珊瑚，产生了四种新的洛巴烷二萜衍生物：环氧洛巴三烯醇和洛巴三烯二醇的乙酸酯同系物（分别为2和7）、洛巴四烯的甲氧基同系物（10）以及洛巴三烯三醇的氧杂环庚三烯同系物（11），还有六种已知衍生物（1、3 - 6和8）。基于核磁共振光谱（1H、13C、COSY、1H检测直接和远程13C - 1H相关）和质谱（EIMS）数据明确确定了新化合物的结构。所有化合物对植物病原真菌黄瓜枝孢均有活性。发现化合物1对革兰氏阳性细菌枯草芽孢杆菌和酵母酿酒酵母有活性。分离得到的洛巴烷二萜在卤虫致死试验中也有活性。在后一种生物测定中，化合物8和10是活性最高的同系物，LC50分别为0.64和4.18微克/毫升。
