Dunaevskaia O N, Shpakova N M
Ukr Biokhim Zh (1978). 1997 Mar-Apr;69(2):30-4.
It has been shown that antihemolytic effect of trifluoroperazine is realized directly at the stage of hyperosmotic stress during cell transfer to 4.0 M NaCl and is not the result of preliminary cell treatment by this amphypathic compound. The value of protecting effect of trifluoroperazine is determined by preliminary RBS dehydration condition. Cell treatment by hemin, modifying cytoskeleton and membrane, significantly affects cell sensitivity to hyperosmotic stress both in the presence of trifluoroperazine and without the latter.
已经表明，三氟拉嗪的抗溶血作用是在细胞转移至4.0M氯化钠时的高渗应激阶段直接实现的，而不是这种两亲性化合物对细胞进行预处理的结果。三氟拉嗪的保护作用值取决于红细胞的初步脱水条件。血红素对细胞骨架和细胞膜进行修饰，无论是在存在三氟拉嗪还是不存在三氟拉嗪的情况下，都能显著影响细胞对高渗应激的敏感性。
