评价长期和单次口服伏马菌素 B₁ 处理的 Wistar 大鼠中的神经鞘脂类。
Evaluation of sphingolipids in Wistar rats treated to prolonged and single oral doses of fumonisin b₁.
机构信息
Departamento de Microbiologia e Imunologia, Instituto de Veterinária da Universidade Federal Rural do Rio de Janeiro, CEP 23890.000, Rio de Janeiro, RJ, Brasil.
Departamento de Bromatologia e Química do Instituto Adolfo Lutz, CEP. 01246-902, São Paulo, Brasil.
出版信息
Int J Mol Sci. 2009 Jan;10(1):50-61. doi: 10.3390/ijms10010050. Epub 2008 Dec 27.
The objective of the present study was to evaluate sphingolipid levels (sphingosine-So and sphinganine-Sa) and to compare the Sa/So ratio in liver, serum and urine of Wistar rats after prolonged administration (21 days) of fumonisin B(1) (FB(1)). In parallel, the kinetics of sphingolipid elimination in urine was studied in animals receiving a single dose of FB(1). Prolonged exposure to FB(1) caused an increase in Sa levels in urine, serum and liver. The most marked effect on sphingolipid biosynthesis was observed in animals treated with the highest dose of FB(1). Animals receiving a single dose of FB(1) presented variations in Sa and So levels and in the Sa/So ratio.
本研究的目的是评估鞘脂水平（神经酰胺 So 和神经酰胺 Sa），并比较长期（21 天）给予伏马菌素 B1（FB1）后 Wistar 大鼠肝、血清和尿液中的 Sa/So 比值。同时，研究了单次给予 FB1 后动物尿液中鞘脂消除的动力学。长时间暴露于 FB1 导致尿液、血清和肝脏中的 Sa 水平升高。在接受最高剂量 FB1 治疗的动物中，观察到对鞘脂生物合成的最显著影响。单次给予 FB1 的动物表现出 Sa 和 So 水平以及 Sa/So 比值的变化。
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