Molina J A, Benito-León J, Jiménez-Jiménez F J, Ortí-Pareja M, Berbel A, Tallón-Barranco A, de Bustos F, Hernánz A
Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain.
Neurosci Lett. 1997 Dec 5;238(3):139-41. doi: 10.1016/s0304-3940(97)00858-6.
We measured total tau protein concentrations in the cerebrospinal fluid (CSF) of 26 non-demented Parkinson's disease (PD) patients and 25 matched controls. When compared with controls, PD patients had similar CSF tau protein concentrations. These values were not correlated with age, age at onset of PD, duration of PD, scores of the Unified PD Rating Scale (UPDRS), and the Hoehn and Yahr staging, and were not influenced significantly by antiparkinsonian drugs. Our results suggest that CSF tau protein levels are apparently unrelated to the risk of PD.
我们测量了26名非痴呆型帕金森病（PD）患者及25名匹配对照者脑脊液（CSF）中的总tau蛋白浓度。与对照组相比，PD患者的脑脊液tau蛋白浓度相似。这些值与年龄、PD发病年龄、PD病程、统一PD评定量表（UPDRS）评分以及Hoehn和Yahr分期均无相关性，且不受抗帕金森病药物的显著影响。我们的结果表明，脑脊液tau蛋白水平显然与PD风险无关。
