Salazar-Aranda R, Sepúlveda-Saavedra J, Waksman de Torres N, Piñeyro-López A, Moreno-Sepúlveda M
Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Mexico.
FEMS Microbiol Lett. 1998 Jan 15;158(2):255-60. doi: 10.1111/j.1574-6968.1998.tb12829.x.
Dimeric anthracenones have been isolated from toxic plants of the genus Karwinskia (Rhamnaceae). T 514 or peroxisomicine A1 is one of the anthracenonic compounds which produce irreversible and selective damage on the peroxisomes of yeast cells in vivo. In this paper we describe the effect of two structurally related anthracenones on cell viability and on the peroxisomes of the methylotrophic yeast Candida boidinii. As has been described for peroxisomicine A1, peroxisomicine A2 and T 544 caused a decrease in the viability of C. boidinii at all concentrations tested, and disruption of the peroxisomal membrane, T 544 showing the strongest effect. In C. boidinii cell death and peroxisomal damage seem to be independent events.
二聚蒽酮已从卡氏藤属（鼠李科）的有毒植物中分离出来。T 514或过氧化物酶体菌素A1是一种蒽醌类化合物，它在体内对酵母细胞的过氧化物酶体产生不可逆的选择性损伤。在本文中，我们描述了两种结构相关的蒽酮对甲基营养型酵母博伊丁假丝酵母细胞活力和过氧化物酶体的影响。正如过氧化物酶体菌素A1所描述的那样，过氧化物酶体菌素A2和T 544在所有测试浓度下均导致博伊丁假丝酵母的活力下降，并破坏过氧化物酶体膜，T 544的作用最强。在博伊丁假丝酵母中，细胞死亡和过氧化物酶体损伤似乎是独立的事件。
