Waksman N, Benavides-Cortez G, Rivas-Galindo V
Departamento de Farmacologia y Toxicologia, Facultad de Medicina, Universidad de Nuevo León, Mexico.
Phytochemistry. 1999 Mar;50(6):1041-6. doi: 10.1016/s0031-9422(98)00587-1.
Tullidinol, a neurotoxin isolated from fruits and roots of several Karwinskia species, was resolved for the first time into two stereoisomers. This was achieved by means of preparative HPLC from roots of Karwinskia parvifolia. Structural assignments were made on the basis of spectroscopic data, including long range correlations as well as geometry optimization by means of semi-empirical methods.
图利地诺醇是从几种卡文斯基属植物的果实和根部分离出的一种神经毒素，首次被拆分为两种立体异构体。这是通过制备型高效液相色谱法从小叶卡文斯基属植物的根部实现的。结构归属是根据光谱数据进行的，包括远程关联以及通过半经验方法进行的几何优化。
