Yonemitsu Y, Komori K, Sueishi K, Sugimachi K
Department of Surgery II, Faculty of Medicine, Kyushu University.
Nihon Rinsho. 1998 Jan;56(1):102-8.
In order to evaluate the pathogenic role of human cytomegalovirus(CMV) infection in human vascular disease, we first examined the role of CMV immediate early gene (CMV-IE) expression in vascular smooth muscle cell (VSMC) proliferation. The in vitro IE gene transfer stimulated VSMC proliferation. The in vivo IE gene transfer showed neointimal thickening while the control arteries did not. In the wall of "so-called" inflammatory abdominal aortic aneurysm (IAAA), CMV infected cells were more frequently encountered than in that of AA and control cases. CMV infected cells were largely identified as macrophages or fibroblasts, and these cells frequently expressed CMV-IE gene. These findings thus suggest that the persistent expression of CMV-IE gene in the vessel wall may play a role in the vascular cellular responses, including progression of atherosclerosis or vasculitis, in vivo.
为了评估人巨细胞病毒（CMV）感染在人类血管疾病中的致病作用，我们首先研究了CMV立即早期基因（CMV-IE）表达在血管平滑肌细胞（VSMC）增殖中的作用。体外IE基因转移刺激了VSMC增殖。体内IE基因转移显示内膜增厚，而对照动脉未出现这种情况。在“所谓的”炎性腹主动脉瘤（IAAA）壁中，与腹主动脉（AA）和对照病例相比，更频繁地发现CMV感染细胞。CMV感染细胞大多被鉴定为巨噬细胞或成纤维细胞，并且这些细胞经常表达CMV-IE基因。因此，这些发现表明，血管壁中CMV-IE基因的持续表达可能在体内血管细胞反应中起作用，包括动脉粥样硬化或血管炎的进展。
