Morris L, Silber E, Sonnenberg P, Eintracht S, Nyoka S, Lyons S F, Saffer D, Koornhof H, Martin D J
National Institute for Virology, Department of Virology, University of the Witwatersrand, Johannesburg, South Africa.
J Infect Dis. 1998 Feb;177(2):473-6. doi: 10.1086/517379.
Thirty-seven matched cerebrospinal fluid (CSF) and plasma samples from 34 human immunodeficiency virus type 1 (HIV-1)-infected patients with suspected meningitis were analyzed for levels of HIV-1 RNA and markers of inflammation. Patients with tuberculous (n = 9) or cryptococcal (n = 6) meningitis had the highest CSF virus loads, which in many cases exceeded the levels in plasma, compared with patients with meningococcal meningitis (n = 3), aseptic meningitis (n = 8), tuberculoma (n = 2), or AIDS dementia complex (n = 4) or with normal lumbar punctures (n = 3). CSF virus load correlated significantly with the number of infiltrating lymphocytes (r = .60, P < .001) but not with plasma virus load, the levels of beta2-microglobulin in the CSF, or the integrity of the blood-brain barrier. These data suggest significant intrathecal HIV-1 replication in patients with lymphocytic meningeal infections such as tuberculous and cryptococcal meningitis.
对34例疑似脑膜炎的人类免疫缺陷病毒1型（HIV-1）感染患者的37对匹配的脑脊液（CSF）和血浆样本进行了HIV-1 RNA水平和炎症标志物分析。与患脑膜炎球菌性脑膜炎（n = 3）、无菌性脑膜炎（n = 8）、结核瘤（n = 2）或艾滋病痴呆综合征（n = 4）的患者或腰椎穿刺正常的患者（n = 3）相比，患有结核性脑膜炎（n = 9）或隐球菌性脑膜炎（n = 6）的患者脑脊液病毒载量最高，在许多情况下超过了血浆中的水平。脑脊液病毒载量与浸润淋巴细胞数量显著相关（r = 0.60，P < 0.001），但与血浆病毒载量、脑脊液中β2-微球蛋白水平或血脑屏障的完整性无关。这些数据表明，在患有结核性和隐球菌性脑膜炎等淋巴细胞性脑膜感染的患者中存在显著的鞘内HIV-1复制。
