Popescu T A, Fekete T, Popescu E, Böjthy I, Laszlo M
Med Interne. 1976 Jan-Mar;14(1):71-3.
The exact role of serum pseudocholinesterase (PSCE) is not known. Its main role probably consists in the degradation of butyril-choline, an intermediate of lipid metabolism. Decreased values have been described in liver cirrhosis as an index of diminished proteosynthetic function. An increased activity of this enzyme was reported in obesity, diabetes mellitus, nephrosis, hyperthyroidism and in hyperlipemic subjects without obesity. A significant correlation was found between serum cholesterol, triglycerides and PSCE, as an expression of lipid metabolism. In view of assessing the possible change of this enzyme during fattening, the authors investigated PSCE activity during fattening in pigs (the same breed). The results indicate a statistically significant increase of PSCE during fattening, from 30.4 +/- 1.7 to 43.6 +/- 1.7 (p less than 0.001). These results together with those reported in a previous paper concerning blood lipids and cholesterol, show a positive correlation between these parameters and PSCE during fattening in pigs, which might be due to an adaptative increase of the hepatic synthesis of this enzyme in response to the increased lipid metabolism.
血清假性胆碱酯酶（PSCE）的确切作用尚不清楚。其主要作用可能在于降解丁酰胆碱，后者是脂质代谢的中间产物。在肝硬化患者中，该酶值降低被视为蛋白质合成功能减弱的指标。据报道，肥胖、糖尿病、肾病、甲状腺功能亢进以及非肥胖的高脂血症患者体内该酶活性增加。作为脂质代谢的一种表现，血清胆固醇、甘油三酯与PSCE之间存在显著相关性。为评估育肥期间该酶可能发生的变化，作者对同一品种猪育肥期间的PSCE活性进行了研究。结果表明，育肥期间PSCE活性有统计学意义的升高，从30.4±1.7升至43.6±1.7（p＜0.001）。这些结果与之前一篇关于血脂和胆固醇的论文报道的结果共同表明，猪育肥期间这些参数与PSCE之间呈正相关，这可能是由于肝脏对该酶的合成适应性增加，以应对脂质代谢的增强。
