Contreras A, Falkler W A, Enwonwu C O, Idigbe E O, Savage K O, Afolabi M B, Onwujekwe D, Rams T E, Slots J
Department of Periodontology, School of Dentistry, University of Southern California, Los Angeles, USA.
Oral Microbiol Immunol. 1997 Oct;12(5):259-65. doi: 10.1111/j.1399-302x.1997.tb00389.x.
Herpesviruses have been implicated in the pathogenesis of human periodontitis. The present study investigated whether herpesviruses are present in the lesions of acute necrotizing ulcerative gingivitis. Sixty-two Nigerian children, aged 3-14 years, were studied. Twenty-two children had acute necrotizing ulcerative gingivitis and were also malnourished, 20 exhibited no acute necrotizing ulcerative gingivitis but were malnourished and 20 were free of acute necrotizing ulcerative gingivitis and in a good nutritional state. Polymerase chain reaction methods were used to determine the presence of human cytomegalovirus (HCMV), Epstein-Barr virus type 1 and type 2 (EBV-1, EBV-2), herpes simplex virus (HSV), human herpes virus 6 (HHV-6), human papilloma virus and human immunodeficiency virus type 1 in crevicular fluid specimens collected by paper points. Of the 22 acute necrotizing ulcerative gingivitis patients, 15 (68%) revealed viral infection and 8 (36%) viral coinfection. Thirteen (59%) acute necrotizing ulcerative gingivitis patients demonstrated HCMV, 6 (27%) EBV-1, 5 (23%) HSV and 1 (5%) HHV-6. Only 2 (10%) subjects from each group not affected by acute necrotizing ulcerative gingivitis showed viral presence, and no control subject revealed viral coinfection. These findings suggest that HCMV and possibly other herpesviruses contribute to the onset and/or progression of acute necrotizing ulcerative gingivitis in malnourished Nigerian children.
疱疹病毒被认为与人类牙周炎的发病机制有关。本研究调查了急性坏死性溃疡性龈炎病变中是否存在疱疹病毒。对62名年龄在3至14岁的尼日利亚儿童进行了研究。22名儿童患有急性坏死性溃疡性龈炎且营养不良，20名未患急性坏死性溃疡性龈炎但营养不良，20名未患急性坏死性溃疡性龈炎且营养状况良好。采用聚合酶链反应方法检测用纸条采集的龈沟液标本中是否存在人巨细胞病毒（HCMV）、1型和2型爱泼斯坦-巴尔病毒（EBV-1、EBV-2）、单纯疱疹病毒（HSV）、人疱疹病毒6型（HHV-6）、人乳头瘤病毒和1型人类免疫缺陷病毒。在22名急性坏死性溃疡性龈炎患者中，15名（68%）出现病毒感染，8名（36%）出现病毒合并感染。13名（59%）急性坏死性溃疡性龈炎患者检测出HCMV，6名（27%）检测出EBV-1，5名（23%）检测出HSV，1名（5%）检测出HHV-6。在未患急性坏死性溃疡性龈炎的每组中，只有2名（10%）受试者检测出病毒存在，且没有对照受试者出现病毒合并感染。这些发现表明，HCMV以及可能的其他疱疹病毒在营养不良的尼日利亚儿童急性坏死性溃疡性龈炎的发病和/或进展中起作用。
