Fontecave M, Lepoivre M, Elleingand E, Gerez C, Guittet O
Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS-CEA/CNRS/Université Joseph Fourier, Grenoble, France.
FEBS Lett. 1998 Jan 16;421(3):277-9. doi: 10.1016/s0014-5793(97)01572-x.
Resveratrol, a natural phytoalexin found in grapes, is well known for its presumed role in the prevention of heart disease, associated with red wine consumption. We show here that it is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further applications as an antiproliferative or a cancer chemopreventive agent in humans.
白藜芦醇是一种在葡萄中发现的天然植保素，因其在预防与饮用红酒相关的心脏病中所起的假定作用而广为人知。我们在此表明，它是哺乳动物细胞中核糖核苷酸还原酶和DNA合成的显著抑制剂，这可能使其在人类中作为抗增殖剂或癌症化学预防剂有进一步的应用。
