Koppenhoefer B, Epperlein U, Christian B, Lin B, Ji Y, Chen Y
University of Tübingen, Germany.
J Chromatogr A. 1996 May 31;735(1-2):333-43. doi: 10.1016/0021-9673(95)01210-9.
Enantiomer separation by capillary zone electrophoresis was studied for a set of 34 chiral drugs. Keeping the concentration of beta-cyclodextrin as a chiral solvating agent as constant as possible led to the separation of seven enantiomeric pairs. Carvedilol, Tetryzoline, Tropicamide and Zopiclone gave a baseline separation, Chlorphenamine, Ketamine, and Orciprenaline a partial separation. Statistical analysis revealed that the best separation factors were observed for a medium degree of interaction with the cyclodextrin. A theory explaining this effect provides a helpful guideline for further optimization.
