选择性环氧化酶-2抑制剂尼美舒利对Min小鼠肠道息肉发展的抑制作用
Suppression of intestinal polyp development by nimesulide, a selective cyclooxygenase-2 inhibitor, in Min mice.
作者信息
Nakatsugi S, Fukutake M, Takahashi M, Fukuda K, Isoi T, Taniguchi Y, Sugimura T, Wakabayashi K
机构信息
Cancer Prevention Division, National Cancer Center Research Institute, Tokyo.
出版信息
Jpn J Cancer Res. 1997 Dec;88(12):1117-20. doi: 10.1111/j.1349-7006.1997.tb00337.x.
Nonsteroidal anti-inflammatory drugs (NSAIDs) suppress colon carcinogenesis in man and experimental animals. However, conventional NSAIDs inhibit both cyclooxygenase (COX) isoforms, COX-1 and COX-2, and cause gastrointestinal side-effects. Nimesulide, a selective inhibitor of COX-2, is much less ulcerogenic. We, therefore, examined its influence on the development of intestinal polyps in Min mice. Female Min mice at 4 weeks old were given 400 ppm nimesulide in their diet for 11 weeks. This treatment resulted in a significant reduction of the numbers of both small and large intestinal polyps, the total being 52% of that in untreated control Min mice. The size of the polyps in the nimesulide-treated group was also significantly decreased. The results suggest that nimesulide is a good candidate as a chemopreventive agent for human colon cancer with low toxicity.
非甾体抗炎药（NSAIDs）可抑制人类和实验动物的结肠癌发生。然而，传统的NSAIDs会同时抑制环氧化酶（COX）的两种同工型，即COX-1和COX-2，并引发胃肠道副作用。尼美舒利是一种COX-2的选择性抑制剂，其致溃疡作用小得多。因此，我们研究了它对Min小鼠肠道息肉发生发展的影响。4周龄的雌性Min小鼠在其饮食中给予400 ppm尼美舒利，持续11周。这种处理导致小肠和大肠息肉数量显著减少，总数为未处理的对照Min小鼠的52%。尼美舒利处理组息肉的大小也显著减小。结果表明，尼美舒利作为一种低毒性的人类结肠癌化学预防剂是一个很好的候选药物。
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