原发性开角型青光眼的氩激光小梁成形术与2%毛果芸香碱对照：两年随访研究

Primary argon laser trabeculoplasty vs pilocarpine 2% in primary open angle glaucoma: two years follow-up study.

作者信息

Sharma A, Gupta A

机构信息

Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

出版信息

Indian J Ophthalmol. 1997 Jun;45(2):109-13.

PMID:9475029

Abstract

In a prospective study, the efficacy of argon laser trabeculoplasty (ALT) was evaluated and compared with pilocarpine 2% as primary treatment in newly diagnosed primary open angle glaucoma (POAG). Out of 38 patients with POAG included in this study, one eye each of 36 patients underwent ALT, and one eye each of 26 patients received pilocarpine 2% every 8 hours. The mean pre-treatment IOP was 25.48 +/- 4.13 mmHg in ALT group and 24.47 +/- 3.51 mmHg in the pilocarpine group. The mean post treatment IOP at 2 year follow was 18.2 +/- 2.55 mmHg in ALT group and 18.27 +/- 2.22 mmHg in the pilocarpine group. Post treatment IOP was significantly lower than pre-treatment IOP in both ALT and pilocarpine groups. The post treatment fall in IOP showed no significant difference in ALT versus pilocarpine 2% at various follow up intervals (p > 0.05). This study showed equal efficacy of ALT and pilocarpine 2% as initial therapy of POAG.

摘要

在一项前瞻性研究中，对氩激光小梁成形术（ALT）的疗效进行了评估，并与2%毛果芸香碱作为新诊断的原发性开角型青光眼（POAG）的初始治疗方法进行了比较。在本研究纳入的38例POAG患者中，36例患者的单眼接受了ALT治疗，26例患者的单眼每8小时接受一次2%毛果芸香碱治疗。ALT组治疗前平均眼压为25.48±4.13 mmHg，毛果芸香碱组为24.47±3.51 mmHg。随访2年时，ALT组治疗后平均眼压为18.2±2.55 mmHg，毛果芸香碱组为18.27±2.22 mmHg。ALT组和毛果芸香碱组治疗后的眼压均显著低于治疗前。在不同随访间隔期，ALT组与2%毛果芸香碱组治疗后眼压下降无显著差异（p>0.05）。本研究表明，ALT和2%毛果芸香碱作为POAG的初始治疗方法疗效相当。