Camargos P A, Guimarães M D, Ferreira C S
Department of Pediatrics, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
J Trop Pediatr. 1997 Dec;43(6):353-60. doi: 10.1093/tropej/43.6.353.
A randomized controlled study was carried out to assess the efficacy of a single dose of benzathine penicillin for treating children 2-12 years old with presumed S. pneumoniae pneumonia. One-hundred-and-seventy-six children screened at self-referral pediatric emergency services in Belo Horizonte, Brazil, were randomized to only one injection of benzathine penicillin (n = 93, case-group) or a 7-day procaine penicillin regimen (n = 83, control-group), upon diagnosis of pneumococcal pneumonia based on clinical and radiological characteristics. Follow-up was carried out on the second day after treatment and around the 7th and/or 14th day after treatment allocation. No statistical significant difference was found for sociodemographic, clinical, laboratory or radiographic characteristics among the two groups. Evident or total radiographic clearing was demonstrated for 92.3 and 95.1 per cent of the benzathine penicillin and procaine penicillin groups, respectively (P = 0.54). Benzathine penicillin may be considered an alternative to classic regimens for treating pneumonia due to sensitive strains of S. pneumoniae among children 2-12 years old. Other benefits are its lower cost, better compliance and low rates of adverse reactions.
开展了一项随机对照研究，以评估单剂量苄星青霉素治疗2至12岁疑似肺炎链球菌肺炎儿童的疗效。在巴西贝洛奥里藏特的儿科急诊服务机构进行自我转诊筛查的176名儿童，根据临床和放射学特征诊断为肺炎球菌肺炎后，被随机分为仅注射一剂苄星青霉素组（n = 93，病例组）或接受7天普鲁卡因青霉素治疗组（n = 83，对照组）。在治疗后第二天以及治疗分配后约第7天和/或第14天进行随访。两组在社会人口统计学、临床、实验室或放射学特征方面未发现统计学显著差异。苄星青霉素组和普鲁卡因青霉素组分别有92.3%和95.1%的患者出现明显或完全的放射学病灶清除（P = 0.54）。对于治疗2至12岁儿童由敏感肺炎链球菌菌株引起的肺炎，苄星青霉素可被视为经典治疗方案的替代方案。其他优点包括成本较低、依从性更好以及不良反应发生率低。
