Cabellos C, Ariza J, Barreiro B, Tubau F, Liñares J, Pallarés R, Manresa F, Gudiol F
Service of Infectious Diseases, Ciutat Sanitària i Universitària de Bellvitge, University of Barcelona, Spain.
Eur J Clin Microbiol Infect Dis. 1998 Apr;17(4):265-8. doi: 10.1007/BF01699983.
The aim of this study was to determine whether procaine penicillin could be used in the treatment of suspected pneumococcal pneumonia of mild to moderate severity in an area with a high prevalence of penicillin resistance. Forty-nine patients were treated with 1.2 x 10(6) U of i.m. procaine penicillin every 12 h. By intent-to-treat analysis, 40 of 49 patients were cured and no patient died. Streptococcus pneumoniae could be demonstrated in 17 patients; 5 of 17 isolates were resistant to penicillin (MICs 0.25-4 microg/ml). Fifteen of 17 patients were cured with procaine penicillin, one presented allergy, and one was a therapeutic failure. Mean penicillin serum levels were 2.39 +/- 1.16 microg/ml (peak) and 0.61 +/- 0.38 microg/ml (trough). The results suggest that procaine penicillin may still be useful in the empirical therapy of suspected pneumococcal pneumonia.
本研究的目的是确定在青霉素耐药率高的地区，普鲁卡因青霉素是否可用于治疗疑似轻至中度严重程度的肺炎球菌肺炎。49例患者每12小时接受1.2×10⁶U的普鲁卡因青霉素肌肉注射治疗。根据意向性分析，49例患者中有40例治愈，无患者死亡。17例患者中分离出肺炎链球菌；17株分离菌中有5株对青霉素耐药（最低抑菌浓度为0.25 - 4μg/ml）。17例患者中有15例用普鲁卡因青霉素治愈，1例出现过敏，1例治疗失败。青霉素血清平均水平为2.39±1.16μg/ml（峰值）和0.61±0.38μg/ml（谷值）。结果表明，普鲁卡因青霉素在疑似肺炎球菌肺炎的经验性治疗中可能仍然有用。
