Rix B A, Villadsen E, Lynge E
Danish Cancer Society, Copenhagen.
Scand J Work Environ Health. 1997 Dec;23(6):458-61. doi: 10.5271/sjweh.269.
Studies have indicated an excess risk of stomach cancer, pancreas cancer, and non-Hodgkin's lymphoma for sulfite pulp mill workers, and therefore cancer incidence was evaluated for 2 Danish sulfite mills.
Altogether 2238 workers employed in 1955--1990 were included in a historic cohort and followed until 31 December 1993. National cancer rates were used to calculate the expected number of cancer cases.
The overall cancer risk was close to the expected, the standardized incidence ratio (SIR) being 1.01. The risk of stomach cancer was doubled [10 observed, SIR 1.99, 95% confidence interval (95% CI) 0.95--3.66], as was the risk of pancreatic cancer (7 observed, SIR 1.88, 95% CI 0.75-3.88). For the men with known pulp exposure, lung cancer was slightly increased (SIR 1.53, 95% CI 0.94-2.37). Other cancers with elevated risks were leukemia (7 observed, SIR 1.84) and soft-tissue sarcomas (4 observed, SIR 2.37). The risk of non-Hodgkin' s lymphoma was not increased.
The excess risk of stomach cancer and pancreatic cancer found in this study was in accordance with that of other studies from sulfite pulp mills.
研究表明,亚硫酸盐制浆厂工人患胃癌、胰腺癌和非霍奇金淋巴瘤的风险较高,因此对两家丹麦亚硫酸盐制浆厂的癌症发病率进行了评估。
1955年至1990年受雇的2238名工人被纳入一个历史性队列,并随访至1993年12月31日。使用全国癌症发病率来计算预期的癌症病例数。
总体癌症风险接近预期,标准化发病比(SIR)为1.01。胃癌风险翻倍[观察到10例,SIR为1.99,95%置信区间(95%CI)为0.95 - 3.66],胰腺癌风险也是如此(观察到7例,SIR为1.88,95%CI为0.75 - 3.88)。对于已知有制浆暴露的男性,肺癌略有增加(SIR为1.53,95%CI为0.94 - 2.37)。其他风险增加的癌症包括白血病(观察到7例,SIR为1.84)和软组织肉瘤(观察到4例,SIR为2.37)。非霍奇金淋巴瘤的风险没有增加。
本研究中发现的胃癌和胰腺癌的额外风险与亚硫酸盐制浆厂的其他研究结果一致。