Rix B A, Villadsen E, Engholm G, Lynge E
Danish Cancer Society, Copenhagen, Denmark.
J Occup Environ Med. 1998 Jan;40(1):55-62. doi: 10.1097/00043764-199801000-00011.
Several studies have indicated an increased cancer risk among paper mill workers, based on rather few cancer cases. The authors studied cancer incidence in a large historical cohort of 14,362 Danish paper mill workers, employed at any time between 1943 and 1990, and followed up until December 31, 1993. Men had an increased risk of pharyngeal cancer (15 observed (obs), standardized incidence ratio (SIR) 1.99, 95% confidence interval (CI) 1.11-3.29). With two additional cases among women, 11 of 17 cases were located in the tonsils. Men also had an increased risk of Hodgkin's disease (18 obs, SIR 2.01, 95% CI 1.19-3.18). Women had an increased risk of soft tissue sarcomas (nine obs, SIR 2.33, 95% CI 1.06-4.43), with a high risk among female paper sorters (eight obs, SIR 3.98, 95% CI 1.71-7.84). The study thus supports some studies' observations of an increased risk of Hodgkin's disease in paper mill workers. The detailed reporting of cancer cases in paper mill workers have furthermore revealed a risk of pharyngeal cancer together with a risk of soft tissue sarcomas in paper sorters.
几项研究表明，造纸厂工人患癌风险增加，不过所依据的癌症病例数相当少。作者对1943年至1990年期间曾在丹麦造纸厂工作的14362名工人这一大型历史队列中的癌症发病率进行了研究，并随访至1993年12月31日。男性患咽癌风险增加（观察到15例，标准化发病比（SIR）为1.99，95%置信区间（CI）为1.11 - 3.29）。女性又有2例，17例病例中有11例位于扁桃体。男性患霍奇金病的风险也增加（观察到18例，SIR为2.01，95% CI为1.19 - 3.18）。女性患软组织肉瘤的风险增加（观察到9例，SIR为2.33，95% CI为1.06 - 4.43），女性纸张分拣工的风险较高（观察到8例，SIR为3.98，95% CI为1.71 - 7.84）。因此，该研究支持了一些研究中关于造纸厂工人患霍奇金病风险增加的观察结果。此外，对造纸厂工人癌症病例的详细报告还揭示了患咽癌的风险以及纸张分拣工患软组织肉瘤的风险。
