Band P R, Le N D, Fang R, Astrakianakis G, Bert J, Keefe A, Krewski D
Cancer Control Research, BC Cancer Agency, Vancouver, Canada.
Scand J Work Environ Health. 2001 Apr;27(2):113-9. doi: 10.5271/sjweh.597.
A study was conducted to investigate cancer risks in a cohort of pulp and paper workers.
All male workers with > or =1 years of employment in 14 pulp and paper mills in 1950-1992 were studied. Standardized incidence ratios (SIR) were used to compare the cancer incidence of the cohort with that of the Canadian male population. Record linkage with the National Cancer Registry was performed using the generalized iterative record linkage method.
Altogether 1756 cancer cases were observed in the entire cohort. For > or =15 years of work, the entire cohort had significantly increased SIR values for pleural and prostate cancer and skin melanoma; there was also a significantly increased risk for skin melanoma among workers in the kraft process only, rectal cancer among workers in the sulfite process only, and stomach and prostate cancer and all leukemias combined among workers in both the kraft and sulfite processes. A separate analysis comparing workers in pulping and papermaking with those in the pulping process only did not reveal any difference in cancer risk and hence did not modify the results. The SIR values for skin melanoma were not significantly increased in a comparison using the British Columbia male population. Nine of 10 pleural cancers were mesotheliomas, which likely reflect past asbestos exposure.
The results suggest that long-term work in the pulp and paper industry is associated with excess risks of prostate and stomach cancers and all leukemias for work in both kraft and sulfite processes and of rectal cancer for work in the sulfite process only.
开展一项研究以调查一群制浆造纸工人的癌症风险。
对1950年至1992年间在14家制浆造纸厂工作≥1年的所有男性工人进行研究。采用标准化发病比（SIR）将该队列的癌症发病率与加拿大男性人群的发病率进行比较。使用广义迭代记录链接方法与国家癌症登记处进行记录链接。
在整个队列中总共观察到1756例癌症病例。工作≥15年时，整个队列中胸膜癌、前列腺癌和皮肤黑色素瘤的SIR值显著升高；仅在硫酸盐制浆工艺工人中皮肤黑色素瘤风险显著增加，仅在亚硫酸盐制浆工艺工人中直肠癌风险显著增加，在硫酸盐制浆和牛皮纸制浆工艺工人中胃癌、前列腺癌以及所有白血病合并的风险显著增加。一项单独分析将制浆造纸工人与仅从事制浆工艺的工人进行比较，未发现癌症风险有任何差异，因此未改变结果。在与不列颠哥伦比亚省男性人群的比较中，皮肤黑色素瘤的SIR值没有显著增加。10例胸膜癌中有9例是间皮瘤，这可能反映了过去接触石棉的情况。
结果表明，在制浆造纸行业长期工作与在硫酸盐制浆和牛皮纸制浆工艺中工作导致的前列腺癌、胃癌以及所有白血病的额外风险相关，仅在亚硫酸盐制浆工艺中工作会导致直肠癌的额外风险。
