Björkstén B, Ray C, Quie P G
Infect Immun. 1976 Jul;14(1):315-7. doi: 10.1128/iai.14.1.315-317.1976.
The effect of the antifungal drugs amphotericin B, fluocytosine, miconazole, griseofulvin, and nystatin on the chemotactic responsiveness of human neutrophils was studied. Amphotericin B in a concentration of 2 mug/ml inhibited chemotatic responsiveness, and in a concentration of 5 mug/ml it also inhibited chemiluminescence. The inhibition of chemotaxis could be reversed by washing the cells. The other antifungal drugs did not inhibit chemotaxis even in concentrations much higher than those obtained in human serum during treatment.
研究了抗真菌药物两性霉素B、氟胞嘧啶、咪康唑、灰黄霉素和制霉菌素对人中性粒细胞趋化反应性的影响。浓度为2微克/毫升的两性霉素B可抑制趋化反应性，浓度为5微克/毫升时还可抑制化学发光。通过洗涤细胞可逆转趋化性的抑制。其他抗真菌药物即使在浓度远高于治疗期间人血清中的浓度时也不抑制趋化性。
