Storms W W, Dick E C, Busse W W
J Allergy Clin Immunol. 1976 Aug;58(2):284-90. doi: 10.1016/0091-6749(76)90133-0.
Attenuated live intranasal influenza vaccine ("Alice") was given to 20 asthmatics and 9 control subjects. Pulmonary function were performed before and after, with emphasis on tests of small airways function (using flow volume curves with air and a helium-oxygen mixture). In subjects with a low influenza A antibody titer, there was a 4-fold rise in titer to the vaccine, whereas those subjects with a high titer showed no rise. There were no significant changes in pulmonary function in any parameters measured, and no significant symptoms were reported. We have concluded from this study that "Alice" appears safe for use in asthma and was capable of producing an antibody titer rise in persons with low titers.
对20名哮喘患者和9名对照受试者接种了减毒活鼻内流感疫苗（“爱丽丝”）。在接种前后进行了肺功能检查，重点是小气道功能测试（使用空气和氦氧混合气体的流量容积曲线）。在甲型流感抗体滴度较低的受试者中，疫苗接种后滴度升高了4倍，而那些高滴度受试者的滴度没有升高。所测量的任何参数的肺功能均无显著变化，也未报告有明显症状。我们从这项研究中得出结论，“爱丽丝”疫苗似乎可安全用于哮喘患者，并且能够使低滴度者的抗体滴度升高。
