Herrero J, Kamali P, Kirschbaum M
Department of Obstetrics and Gynaecology, University of Giessen, Germany.
Eur J Obstet Gynecol Reprod Biol. 1998 Feb;76(2):189-91. doi: 10.1016/s0301-2115(97)00173-5.
Leiomyomatosis peritonealis disseminata (LPD) is a rare disease characterised by the presence of multiple smooth muscle tumour nodules throughout the peritoneal cavity. Approximately 50 cases of LPD have been reported to date in the world literature. There is a very high association with excess exogenous and endogenous female gonadal steroids, specifically oestrogen and progesterone. LPD has been described almost only in premenopausal women and is mostly asymptomatic. Four cases of malignant transformation of this disease have been reported. We report a case of a patient with prolonged exposure to oral contraceptives, operated because of hypermenorrhea and 'myoma in statu nascendi'. A metastasing myomatous tumour was suspected during the operation. LPD was diagnosed by intraoperative histological examination. Abdominal hysterectomy was performed. Five months later a second laparotomy had to be done because of an ovarian endometriosis tumour of about 10 cm size. A bilateral salpingo-oophorectomy and omentectomy were performed.
播散性腹膜平滑肌瘤病（LPD）是一种罕见疾病，其特征是在整个腹膜腔内存在多个平滑肌肿瘤结节。迄今为止，世界文献中已报道了约50例LPD病例。它与外源性和内源性女性性腺类固醇过多，特别是雌激素和孕激素有非常高的相关性。LPD几乎仅在绝经前女性中被描述，且大多无症状。该疾病已有4例恶变的报道。我们报告了1例长期服用口服避孕药的患者，因月经过多和“初发肌瘤”接受手术。术中怀疑为转移性肌瘤样肿瘤。通过术中组织学检查诊断为LPD。实施了腹式子宫切除术。5个月后，因一个约10厘米大小的卵巢子宫内膜异位瘤不得不再次进行剖腹手术。实施了双侧输卵管卵巢切除术和大网膜切除术。
