Uhle R A, Reader A, Nist R, Weaver J, Beck M, Meyers W J
Section of Endodontics, College of Dentistry, Ohio State University, Columbus 43210, USA.
Anesth Prog. 1997 Summer;44(3):90-5.
The purpose of this study was to investigate the ability of low-dose fentanyl to produce analgesia when administered via the periodontal ligament injection in teeth with symptomatic, inflamed pulps. All subjects presented for emergency treatment with moderate to severe pain and had a posterior tooth with a clinical diagnosis of irreversible pulpitis. Twenty subjects randomly received either 10 micrograms fentanyl citrate or saline placebo via the periodontal ligament injection in a double-blind manner. The subjects rated their pain prior to injection and rated pain intensity and pain half gone for 59 min postinjection. Low-dose fentanyl delivered via the periodontal ligament injection in inflamed teeth provided significantly greater analgesia than the saline placebo (P < 0.05). Since the dose of fentanyl used was less than the dose required to provide analgesia by a central mechanism, the results of this study may be consistent with a peripheral opioid mechanism of action.
本研究的目的是调查低剂量芬太尼经牙周膜注射用于有症状的、发炎牙髓的牙齿时产生镇痛作用的能力。所有受试者因中度至重度疼痛前来接受急诊治疗，且有一颗临床诊断为不可逆性牙髓炎的后牙。20名受试者以双盲方式经牙周膜注射随机接受10微克枸橼酸芬太尼或生理盐水安慰剂。受试者在注射前对疼痛进行评分，并在注射后59分钟对疼痛强度和疼痛减轻一半的时间进行评分。在发炎牙齿中经牙周膜注射低剂量芬太尼产生的镇痛作用明显强于生理盐水安慰剂（P < 0.05）。由于所用芬太尼的剂量低于通过中枢机制产生镇痛作用所需的剂量，本研究结果可能与外周阿片类作用机制一致。
