Bourin M, Baker G B, Bradwejn J
GIS Médicament, Groupe de Recherche Neurobiologie de l'anxiété ER 302, Faculté de Médecine, Nantes, France.
J Psychosom Res. 1998 Jan;44(1):163-80. doi: 10.1016/s0022-3999(97)00203-1.
Various provocative agents, including sodium lactate, carbon dioxide (CO2), caffeine, yohimbine, serotoninergic agents, and cholecystokinin (CCK), have been utilized as panicogenics in studies on healthy volunteers as well as in panic disorder patients. An overview of the utilization of these agents to study the neurobiology of panic disorder is presented. The possible roles of several neurotransmitters and neuromodulators in the etiology of panic disorder and in the actions of drugs used in its treatment are also discussed.
包括乳酸钠、二氧化碳（CO₂）、咖啡因、育亨宾、5-羟色胺能药物和胆囊收缩素（CCK）在内的多种激发剂，已被用作致惊恐剂，用于对健康志愿者以及惊恐障碍患者的研究。本文对这些激发剂在惊恐障碍神经生物学研究中的应用进行了综述。还讨论了几种神经递质和神经调节剂在惊恐障碍病因以及其治疗所用药物作用中的可能作用。
