Prince M, Rabe-Hesketh S, Brennan P
Section of Epidemiology and General Practice, Institute of Psychiatry, London, UK.
Neurology. 1998 Feb;50(2):374-9. doi: 10.1212/wnl.50.2.374.
We ascertained nonsteroidal anti-inflammatory drug (NSAID) use in 2,651 participants in the UK MRC treatment trial of hypertension in older adults and measured change in cognitive function over the subsequent 54 months. There was a significant, although modest, association between change in the Paired Associate Learning Test score over time and NSAID use, which was modified by age. NSAID users showed less decline, with younger subjects seeming to benefit more than older. We found no relationship between NSAID use and time taken to complete the Trail Making Test and also no relationship between anti-indigestion drug use and either cognitive outcome. These analyses highlight the need for larger studies with prospective classification of NSAID use and adequate control of confounding, including exposure to other medications. A randomized controlled trial of NSAIDs, in those known to be at risk of cognitive decline or dementia, may be indicated in the future.
我们确定了英国医学研究委员会（MRC）针对老年人高血压治疗试验中2651名参与者的非甾体抗炎药（NSAID）使用情况，并测量了随后54个月内认知功能的变化。随着时间推移，配对联想学习测试分数的变化与NSAID使用之间存在显著关联，不过关联程度较小，且这种关联受年龄影响。NSAID使用者的认知功能衰退程度较小，年轻受试者似乎比年长受试者受益更多。我们发现NSAID使用与完成连线测验所需时间之间没有关系，同时抗消化不良药物使用与任何一种认知结果之间也没有关系。这些分析凸显了开展更大规模研究的必要性，这类研究需对NSAID使用进行前瞻性分类，并充分控制混杂因素，包括其他药物暴露情况。未来可能需要针对已知有认知衰退或痴呆风险的人群开展NSAIDs的随机对照试验。
