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切尔诺贝利事故“清理人”中的甲状腺癌。

Thyroid cancer among "liquidators" of the Chernobyl accident.

作者信息

Ivanov V K, Tsyb A F, Gorsky A I, Maksyutov M A, Rastopchin E M, Konogorov A P, Biryukov A P, Matyash V A, Mould R F

机构信息

Medical Radiological Research Centre, Russian Academy of Medical Sciences, Obninsk, Russia.

出版信息

Br J Radiol. 1997 Sep;70(837):937-41. doi: 10.1259/bjr.70.837.9486071.

DOI:10.1259/bjr.70.837.9486071
PMID:9486071
Abstract

In 1986, immediately after the Chernobyl accident, the USSR Ministry of Health adopted a large scale programme of establishing an All-Union Distributed Registry of persons affected by radiation due to the accident. The registry was based at the Medical Radiological Research Centre of the Russian Academy of Medical Sciences (MRRC RAMS). In 1992, when the USSR was dissolved, this registry database contained information on 659,000 persons, including 284,000 Chernobyl accident emergency workers ("liquidators"). Currently, the Russian National Medical Dosimetric Registry (RNMDR) contains data on 435,276 persons, including 167,862 liquidators. This paper reviews the data for 47 verified thyroid cancers in the liquidator subgroup of the RNMDR. Analyses show that there is an excess relative risk of thyroid cancer per Gy of 5.31 (95% confidence intervals 0.04 and 10.58) and an excess absolute risk of thyroid cancer per 10(4) person-years per Gy of 1.15 (95% confidence intervals 0.08 and 2.22).

摘要

1986年,切尔诺贝利事故发生后,苏联卫生部立即启动了一项大规模计划,旨在建立全联盟范围内受该事故辐射影响人员的分布式登记册。该登记册以俄罗斯医学科学院医学放射学研究中心(MRRC RAMS)为基地。1992年苏联解体时,该登记册数据库包含了65.9万人的信息,其中包括28.4万名切尔诺贝利事故应急工作人员(“清理人”)。目前,俄罗斯国家医学剂量测定登记册(RNMDR)包含了435276人的数据,其中包括167862名清理人。本文回顾了RNMDR清理人亚组中47例经核实的甲状腺癌数据。分析表明,每戈瑞甲状腺癌的超额相对风险为5.31(95%置信区间为0.04和10.58),每10(4)人年每戈瑞甲状腺癌的超额绝对风险为1.15(95%置信区间为0.08和2.22)。

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