Shir Y, Ratner A, Raja S N, Campbell J N, Seltzer Z
Department of Anesthesiology and Pain Relief Service, Hadassah University Hospital, Jerusalem, Israel.
Neurosci Lett. 1998 Jan 9;240(2):73-6. doi: 10.1016/s0304-3940(97)00923-3.
Some humans with partial nerve injury present a syndrome of neuropathic sensory disorders which depend on the sympathetic activity (sympathetically-maintained pain, SMP). Several years ago we introduced a rat model for SMP, produced by tightly ligating 1/3-1/2 of the sciatic nerve, leading to a partial denervation of the hindpaw (Partial Sciatic Ligation, PSL model) [Seltzer, Z., Dubner, R. and Shir, Y., Pain, 43 (1990) 245-250]. After working with this model for several years we encountered difficulties in replicating it although rat strain, vendor, gender, age and weight, surgical approach and sensory testing procedures were not changed. We report here that this variability can be attributed, at least in part, to the diet the animals consumed. Rats fed perioperatively with soy-containing diets expressed significantly weaker neuropathic sensory disorders compared to rats fed on soy-free diets. We conclude that diet may greatly affect experimental outcome in the PSL model.
一些患有部分神经损伤的人会出现一种取决于交感神经活动的神经性感觉障碍综合征（交感神经维持性疼痛，SMP）。几年前，我们引入了一种SMP大鼠模型，通过紧密结扎坐骨神经的1/3 - 1/2来产生，导致后爪部分去神经支配（部分坐骨神经结扎，PSL模型）[Seltzer, Z., Dubner, R.和Shir, Y., Pain, 43 (1990) 245 - 250]。在使用这个模型几年后，尽管大鼠品系、供应商、性别、年龄和体重、手术方法以及感觉测试程序都没有改变，但我们在复制该模型时遇到了困难。我们在此报告，这种变异性至少部分可归因于动物所食用的饮食。与食用不含大豆饮食的大鼠相比，围手术期喂食含大豆饮食的大鼠表现出明显较弱的神经性感觉障碍。我们得出结论，饮食可能会极大地影响PSL模型的实验结果。
