Erjefält J S, Persson C G
Department of Physiology and Neuroscience, University Hospital, Lund, Sweden.
Thorax. 1997 Nov;52(11):1010-2. doi: 10.1136/thx.52.11.1010.
Epithelial shedding, even to the point of airway denudation, had already been described as a common and unifying feature of asthma by the latter half of the 19th century. However, the repair processes that specifically follow the shedding-like loss of epithelial cells have only recently been examined in vivo. This paper discusses the exceedingly fast epithelial restitution and the potential pathogenic sequelae to epithelial shedding alone that have been unravelled. Epithelial cytoprotection emerges as an important property of future therapeutic drugs for the treatment of airways inflammatory conditions.
上皮脱落，甚至达到气道剥脱的程度，早在19世纪后半叶就已被描述为哮喘的一个常见且统一的特征。然而，上皮细胞类似脱落性丢失后所特有的修复过程直到最近才在体内进行研究。本文讨论了已被揭示的极其快速的上皮修复以及仅由上皮脱落引发的潜在致病后遗症。上皮细胞保护作用已成为未来治疗气道炎症性疾病药物的一项重要特性。
