Tornieporth N G, Ptachewich Y, Poltoratskaia N, Ravi B S, Katapadi M, Berger J J, Dahdouh M, Segal-Maurer S, Glatt A, Adamis R, Lerner C, Armstrong D, Weiner M, D'Amato R, Kiehn T, Lavie S, Stoeckle M Y, Riley L W
Department of Medicine, Cornell University Medical College, New York, New York, USA.
Int J Tuberc Lung Dis. 1997 Dec;1(6):528-35.
To study the pattern of transmission of tuberculosis (TB) among foreign-born persons living in New York City.
A retrospective multicenter study comparing 158 foreign-born patients to 231 US-born patients diagnosed with TB between 1992 and 1994. The patients were stratified according to their Mycobacterium tuberculosis isolate DNA fingerprint patterns.
Nineteen (16%) of 122 isolates from foreign-born TB patients and 75 (42%) of 180 isolates from US-born TB patients had DNA fingerprint patterns (cluster patterns) indicative of recent exogenous transmission (P < 0.001). All cluster pattern strains from foreign-born cases were identical to those found among US-born patients. The likelihood of infection with a cluster pattern strain among foreign-born persons increased with duration of residence in the US, and was significantly associated with being homeless (P < 0.05), or having multidrug-resistant TB (P = 0.00072).
Although most (84%) cases of TB among foreign-born persons in New York City appear to result from reactivation of infections they acquired abroad, the ones who acquire new infections become infected with strains that are already circulating among the US-born TB patients in New York City, and they have risk factors similar to those faced by US-born tuberculosis patients.
研究居住在纽约市的外国出生人群中结核病（TB）的传播模式。
一项回顾性多中心研究，比较了1992年至1994年间确诊为结核病的158名外国出生患者和231名美国出生患者。根据结核分枝杆菌分离株的DNA指纹图谱对患者进行分层。
122例外国出生的结核病患者分离株中有19例（16%），180例美国出生的结核病患者分离株中有75例（42%）具有表明近期外源性传播的DNA指纹图谱（聚类图谱）（P<0.001）。外国出生病例的所有聚类图谱菌株与美国出生患者中发现的菌株相同。外国出生人群中感染聚类图谱菌株的可能性随着在美国居住时间的延长而增加，并且与无家可归（P<0.05）或患有耐多药结核病（P=0.00072）显著相关。
虽然纽约市外国出生人群中的大多数（84%）结核病病例似乎是由他们在国外获得的感染复发引起的，但那些获得新感染的人感染的是已经在纽约市美国出生的结核病患者中传播的菌株，并且他们具有与美国出生的结核病患者相似的危险因素。
