Jasmer R M, Ponce de Leon A, Hopewell P C, Alarcon R G, Moss A R, Paz E A, Schecter G F, Small P M
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital Medical Center, California, USA.
Int J Tuberc Lung Dis. 1997 Dec;1(6):536-41.
San Francisco, California.
To determine the relative contributions of infection acquired in San Francisco and reactivation of tuberculous infection acquired elsewhere in Mexican-born persons who developed tuberculosis in San Francisco, and to determine the frequency of transmission leading to secondary cases of tuberculosis in other persons.
The study population consisted of all Mexican-born tuberculosis patients reported in San Francisco from 1991 through June 1995. All patients had positive cultures for Mycobacterium tuberculosis and DNA fingerprinting of isolates using IS6110 with more than two bands. Patients were classified as infected in San Francisco or infected elsewhere based on pre-defined criteria that included a second DNA fingerprinting technique (polymorphic guanine-cytosine-rich sequence), chart reviews, and selected patient interviews.
Of the 43 Mexican-born patients studied, nine (21%) met the definition of infection acquired in San Francisco and 34 (79%) met the definition of reactivation of infection acquired elsewhere. Only one of the 43 cases resulted in two secondary cases in US-born persons.
One-fifth of the Mexican-born patients who developed tuberculosis in San Francisco acquired their tuberculous infection in San Francisco; transmission from Mexican-born persons leading to tuberculosis in other persons is uncommon.
加利福尼亚州旧金山。
确定在旧金山患结核病的墨西哥出生者中，在旧金山获得的感染以及在其他地方获得的结核感染再激活的相对贡献，并确定导致其他人患继发性结核病病例的传播频率。
研究人群包括1991年至1995年6月在旧金山报告的所有墨西哥出生的结核病患者。所有患者结核分枝杆菌培养均呈阳性，并使用具有两条以上条带的IS6110对分离株进行DNA指纹分析。根据预先定义的标准，包括第二种DNA指纹分析技术（富含鸟嘌呤 - 胞嘧啶的多态序列）、病历审查和选定患者访谈，将患者分类为在旧金山感染或在其他地方感染。
在研究的43名墨西哥出生的患者中，9名（21%）符合在旧金山获得感染的定义，34名（79%）符合在其他地方获得的感染再激活的定义。43例病例中只有1例导致美国出生的人出现2例继发性病例。
在旧金山患结核病的墨西哥出生患者中，五分之一在旧金山获得结核感染；墨西哥出生的人传播导致其他人患结核病的情况并不常见。
