Grunwald J E, Hariprasad S M, DuPont J
Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, USA.
Arch Ophthalmol. 1998 Feb;116(2):150-4. doi: 10.1001/archopht.116.2.150.
To determine the effect of aging on choroidal blood flow (ChBFlow) in the foveolar region of the normal ocular fundus.
Choroidal blood flow was determined using laser Doppler flowmetry. Twenty-nine eyes of 29 normal subjects whose ages ranged from 15 to 76 years (mean+/-SD, 42+/-18 years) were included in this study. Relative choroidal blood velocity (ChBVel), choroidal blood volume (ChBVol), and ChBFlow were determined in the foveolar region by asking the subjects to fixate on the probing laser beam.
Significant negative correlations were observed between ChBVol and the subject's age (R=-0.52, P=.004) and between ChBFlow and the subject's age (R=-0.54, P=.003). No significant correlation was detected between ChBVel and the subject's age (R=0.07, P=.70). Significant differences were observed in ChBVol and ChBFlow between the younger subjects aged 15 to 45 years (mean+/-SD, 0.48+/-0.20 arbitrary units [AU] and 18.9+/-5.8 AU, respectively) and the older ones aged 46 to 76 years (mean+/-SD, 0.34+/-0.11 AU and 13.3+/-3.3 AU, respectively; unpaired Student t test, P=.04 and P=.007, respectively).
In the subjects studied, foveolar ChBFlow decreases with age. This change is probably related to the decrease in density and diameter of the choriocapillaries that occurs with increasing age.
确定衰老对正常眼底黄斑中心凹区域脉络膜血流（ChBFlow）的影响。
使用激光多普勒血流仪测定脉络膜血流。本研究纳入了29名年龄在15至76岁（平均±标准差，42±18岁）的正常受试者的29只眼睛。通过让受试者注视探测激光束，测定黄斑中心凹区域的相对脉络膜血流速度（ChBVel）、脉络膜血容量（ChBVol）和ChBFlow。
ChBVol与受试者年龄之间（R = -0.52，P = 0.004）以及ChBFlow与受试者年龄之间（R = -0.54，P = 0.003）观察到显著的负相关。未检测到ChBVel与受试者年龄之间的显著相关性（R = 0.07，P = 0.70）。年龄在15至45岁的年轻受试者（平均±标准差，分别为0.48±0.20任意单位[AU]和18.9±5.8 AU）与年龄在46至76岁的年长受试者（平均±标准差，分别为0.34±0.11 AU和13.3±3.3 AU）之间，ChBVol和ChBFlow存在显著差异（未配对学生t检验，P分别为0.04和0.007）。
在所研究的受试者中，黄斑中心凹ChBFlow随年龄增长而降低。这种变化可能与随着年龄增长脉络膜毛细血管密度和直径的降低有关。
